Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol

Jae Hyun Jeong, John J. Schmidt, Richie E. Kohman, Andrew T. Zill, Ross J. Devolder, Cartney E. Smith, Mei Hsiu Lai, Artem Shkumatov, Tor W. Jensen, Lawrence G. Schook, Steven C. Zimmerman, Hyunjoon Kong

Research output: Contribution to journalArticle

Abstract

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

Original languageEnglish (US)
Pages (from-to)8770-8773
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number24
DOIs
StatePublished - Jun 19 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Jeong, J. H., Schmidt, J. J., Kohman, R. E., Zill, A. T., Devolder, R. J., Smith, C. E., Lai, M. H., Shkumatov, A., Jensen, T. W., Schook, L. G., Zimmerman, S. C., & Kong, H. (2013). Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol. Journal of the American Chemical Society, 135(24), 8770-8773. https://doi.org/10.1021/ja400636d