Abstract
Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility required during set-shifting. Using electroencephalography (EEG) in 23 patients with focal frontal lobe lesions (resected tumors), we tested the hypothesis that the FP network is necessary for modulation of high-α band phase synchrony. Global phase-synchrony was measured using an adaptation of the phase-locking value (PLV) in a sliding window procedure, which allowed for measurement of changes in EEG-based resting-state functional connectivity across time. As hypothesized, the temporal modulation (range and standard deviation) of high-α phase synchrony was reduced as a function of FP network lesion extent, mostly due to dorsolateral prefrontal cortex (dlPFC) lesions. Furthermore, patients with dlPFC lesions exhibited reduced cognitive flexibility as measured by the Trail-Making Test (set-shifting). Our findings provide evidence that the FP network is necessary for modulatory control of high-α band long-range phase synchrony, and linked to cognitive flexibility.
Original language | English (US) |
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Article number | bhy296 |
Pages (from-to) | 4143-4153 |
Number of pages | 11 |
Journal | Cerebral Cortex |
Volume | 29 |
Issue number | 10 |
Early online date | Dec 7 2018 |
DOIs | |
State | Published - Sep 13 2019 |
Keywords
- alpha oscillations
- cognitive flexibility
- dorsolateral prefrontal cortex
- fronto-parietal network
- lesion
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience