Lengthscales and cooperativity in DNA bubble formation

Z. Rapti, A. Smerzi, K. Rasmussen, A. R. Bishop, C. H. Choi, A. Usheva

Research output: Contribution to journalArticlepeer-review

Abstract

It appears that thermally activated DNA bubbles of different sizes play central roles in important genetic processes. Here we show that the probability for the formation of such bubbles is regulated by the number of adenine-thymine pairs in specific regions with lengths which at physiological temperatures are of the order of (but not equal to) the size of the bubble. Our analysis is based on the Peyrard-Bishop-Dauxois model, whose equilibrium statistical properties have been accurately calculated here with a transfer integral approach.

Original languageEnglish (US)
Pages (from-to)540-546
Number of pages7
JournalEurophysics Letters
Volume74
Issue number3
DOIs
StatePublished - May 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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