TY - JOUR
T1 - Legume-derived bioactive peptides
T2 - role in cardiovascular disease prevention and control
AU - Fonseca Hernandez, David
AU - Mojica, Luis
AU - Gonzalez de Mejia, Elvira
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/4
Y1 - 2024/4
N2 - Cardiovascular diseases (CVDs) are a health problem worldwide. The use of peptides and protein hydrolysates derived from legumes to prevent and treat them has increased in recent years. In vitro and in vivo data support the efficacy of peptide interaction with markers associated with hypertension, endothelium dysfunction, and atherosclerosis. However, challenges such as misunderstanding their mechanism of action, safety, bioavailability, bitter taste, and cost-effective production limit their clinical and commercial translation. We analyzed and summarized recent findings related to legume-derived peptides and their mechanism of action associated with CVDs, including novel target markers associated with lipid metabolism, such as the inflammasome, angiopoietin-like protein 3, and proprotein convertase subtilisin/kexin 9.
AB - Cardiovascular diseases (CVDs) are a health problem worldwide. The use of peptides and protein hydrolysates derived from legumes to prevent and treat them has increased in recent years. In vitro and in vivo data support the efficacy of peptide interaction with markers associated with hypertension, endothelium dysfunction, and atherosclerosis. However, challenges such as misunderstanding their mechanism of action, safety, bioavailability, bitter taste, and cost-effective production limit their clinical and commercial translation. We analyzed and summarized recent findings related to legume-derived peptides and their mechanism of action associated with CVDs, including novel target markers associated with lipid metabolism, such as the inflammasome, angiopoietin-like protein 3, and proprotein convertase subtilisin/kexin 9.
UR - http://www.scopus.com/inward/record.url?scp=85185446472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85185446472&partnerID=8YFLogxK
U2 - 10.1016/j.cofs.2024.101132
DO - 10.1016/j.cofs.2024.101132
M3 - Review article
AN - SCOPUS:85185446472
SN - 2214-7993
VL - 56
JO - Current Opinion in Food Science
JF - Current Opinion in Food Science
M1 - 101132
ER -