Legume-derived bioactive peptides: role in cardiovascular disease prevention and control

David Fonseca Hernandez, Luis Mojica, Elvira Gonzalez de Mejia

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiovascular diseases (CVDs) are a health problem worldwide. The use of peptides and protein hydrolysates derived from legumes to prevent and treat them has increased in recent years. In vitro and in vivo data support the efficacy of peptide interaction with markers associated with hypertension, endothelium dysfunction, and atherosclerosis. However, challenges such as misunderstanding their mechanism of action, safety, bioavailability, bitter taste, and cost-effective production limit their clinical and commercial translation. We analyzed and summarized recent findings related to legume-derived peptides and their mechanism of action associated with CVDs, including novel target markers associated with lipid metabolism, such as the inflammasome, angiopoietin-like protein 3, and proprotein convertase subtilisin/kexin 9.

Original languageEnglish (US)
Article number101132
JournalCurrent Opinion in Food Science
Volume56
DOIs
StatePublished - Apr 2024

ASJC Scopus subject areas

  • Food Science
  • Applied Microbiology and Biotechnology

Fingerprint

Dive into the research topics of 'Legume-derived bioactive peptides: role in cardiovascular disease prevention and control'. Together they form a unique fingerprint.

Cite this