@article{3f5b42ba0bca4323a754ceef1eccd259,
title = "Leginon: A system for fully automated acquisition of 1000 electron micrographs a day",
abstract = "We have developed a system to automatically acquire large numbers of acceptable quality images from specimens of negatively stained catalase, a biological protein which forms crystals. In this paper we will describe the details of the system architecture and analyze the performance of the system as compared to a human operator. The ultimate goal of the system if to automate the process of acquiring cryo-electron micrographs.",
keywords = "Automated data acquisition, Instrument control, Microscopic methods, Three- dimensional electron microscopy",
author = "Potter, {C. S.} and H. Chu and B. Frey and C. Green and N. Kisseberth and Madden, {T. J.} and Miller, {K. L.} and K. Nahrstedt and J. Pulokas and A. Reilein and D. Tcheng and D. Weber and B. Carragher",
note = "Funding Information: We thank Robert Josephs (University of Chicago) for his suggestion of using catalase as a test system and providing our initial specimen grids. Financial support and equipment was provided by the National Science Foundation (DBI-9730056) and the International Business Machines Shared University Research program. Nahrstedt's research was supported by the National Science Foundation Career Grant (CCR-96-23867) and the National Computational Science Alliance. We are grateful to both the Beckman Institute and the National Center for Supercomputing Applications for institutional support. ",
year = "1999",
month = jul,
doi = "10.1016/S0304-3991(99)00043-1",
language = "English (US)",
volume = "77",
pages = "153--161",
journal = "Ultramicroscopy",
issn = "0304-3991",
publisher = "Elsevier B.V.",
number = "3-4",
}