TY - JOUR
T1 - Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock-Environment-Plant-Human Health Axis and Microbial Homeostasis
T2 - A Review
AU - Zhen, Yongkang
AU - Ge, Ling
AU - Chen, Qiaoqing
AU - Xu, Jun
AU - Duan, Zhenyu
AU - Loor, Juan J.
AU - Wang, Mengzhi
N1 - This work was supported by the National 13th Five-Year Plan Key Research and Development Program (2017YFD0800200 and 2018YFD0502100), Jiangxi Key Research and Development Program (20201BBF61008), Environmental Control Innovation Team of Jiangsu Modern Agriculture (Pig) Industrial Technology System [JATS(2020)323], Key Program of State Key Laboratory of Sheep Genetic Improvement and Healthy Production (2021ZD07, 2021ZD01, SKLSGIHP2021A03), and Priority Academic Program Development of Jiangsu Higher Education Institutions, China.
PY - 2022/6/15
Y1 - 2022/6/15
N2 - The extensive use of high-concentration copper (Cu) in feed additives, fertilizers, pesticides, and nanoparticles (NPs) inevitably causes significant pollution in the ecological environment. This type of chain pollution begins with animal husbandry: first, Cu accumulation in animals poisons them; second, high Cu enters the soil and water sources with the feces and urine to cause toxicity, which may further lead to crop and plant pollution; third, this process ultimately endangers human health through consumption of livestock products, aquatic foods, plants, and even drinking water. High Cu potentially alters the antibiotic resistance of soil and water sources and further aggravates human disease risks. Thus, it is necessary to formulate reasonable Cu emission regulations because the benefits of Cu for livestock and plants cannot be ignored. The present review evaluates the potential hazards and benefits of high Cu in livestock, the environment, the plant industry, and human health. We also discuss aspects related to bacterial and fungal resistance and homeostasis and perspectives on the application of Cu-NPs and microbial high-Cu removal technology to reduce the spread of toxicity risks to humans.
AB - The extensive use of high-concentration copper (Cu) in feed additives, fertilizers, pesticides, and nanoparticles (NPs) inevitably causes significant pollution in the ecological environment. This type of chain pollution begins with animal husbandry: first, Cu accumulation in animals poisons them; second, high Cu enters the soil and water sources with the feces and urine to cause toxicity, which may further lead to crop and plant pollution; third, this process ultimately endangers human health through consumption of livestock products, aquatic foods, plants, and even drinking water. High Cu potentially alters the antibiotic resistance of soil and water sources and further aggravates human disease risks. Thus, it is necessary to formulate reasonable Cu emission regulations because the benefits of Cu for livestock and plants cannot be ignored. The present review evaluates the potential hazards and benefits of high Cu in livestock, the environment, the plant industry, and human health. We also discuss aspects related to bacterial and fungal resistance and homeostasis and perspectives on the application of Cu-NPs and microbial high-Cu removal technology to reduce the spread of toxicity risks to humans.
KW - antibiotic resistance
KW - copper
KW - livestock
KW - microbial homeostasis
KW - plants
KW - toxicity
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U2 - 10.1021/acs.jafc.2c01367
DO - 10.1021/acs.jafc.2c01367
M3 - Review article
C2 - 35666880
AN - SCOPUS:85132131147
SN - 0021-8561
VL - 70
SP - 6943
EP - 6962
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 23
ER -