Large Scale Parallel DNA Detection by Two-Dimensional Solid-State Multipore Systems

Nagendra Bala Murali Athreya, Aditya Sarathy, Jean Pierre Leburton

Research output: Contribution to journalArticlepeer-review


We describe a scalable device design of a dense array of multiple nanopores made from nanoscale semiconductor materials to detect and identify translocations of many biomolecules in a massively parallel detection scheme. We use molecular dynamics coupled to nanoscale device simulations to illustrate the ability of this device setup to uniquely identify DNA parallel translocations. We show that the transverse sheet currents along membranes are immune to the crosstalk effects arising from simultaneous translocations of biomolecules through multiple pores, due to their ability to sense only the local potential changes. We also show that electronic sensing across the nanopore membrane offers a higher detection resolution compared to ionic current blocking technique in a multipore setup, irrespective of the irregularities that occur while fabricating the nanopores in a two-dimensional membrane.

Original languageEnglish (US)
Pages (from-to)1032-1039
Number of pages8
JournalACS Sensors
Issue number5
StatePublished - May 25 2018


  • electronic transport
  • molecular dynamics
  • multiple nanopores
  • solid-state nanopores
  • two-dimensional materials

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes


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