Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring

Limei Tian, Benjamin Zimmerman, Aadeel Akhtar, Ki Jun Yu, Matthew Moore, Jian Wu, Ryan J. Larsen, Jung Woo Lee, Jinghua Li, Yuhao Liu, Brian Metzger, Subing Qu, Xiaogang Guo, Kyle E. Mathewson, Jonathan A. Fan, Jesse Cornman, Michael Fatina, Zhaoqian Xie, Yinji Ma, Jue ZhangYihui Zhang, Florin Dolcos, Monica Fabiani, Gabriele Gratton, Timothy Wolfe Bretl, Levi J. Hargrove, Paul V Braun, Yonggang Huang, John A. Rogers

Research output: Contribution to journalArticle

Abstract

Skin-interfaced medical devices are critically important for diagnosing disease, monitoring physiological health and establishing control interfaces with prosthetics, computer systems and wearable robotic devices. Skin-like epidermal electronic technologies can support these use cases in soft and ultrathin materials that conformally interface with the skin in a manner that is mechanically and thermally imperceptible. Nevertheless, schemes so far have limited the overall sizes of these devices to less than a few square centimetres. Here, we present materials, device structures, handling and mounting methods, and manufacturing approaches that enable epidermal electronic interfaces that are orders of magnitude larger than previously realized. As a proof-of-concept, we demonstrate devices for electrophysiological recordings that enable coverage of the full scalp and the full circumference of the forearm. Filamentary conductive architectures in open-network designs minimize radio frequency-induced eddy currents, forming the basis for structural and functional compatibility with magnetic resonance imaging. We demonstrate the use of the large-area interfaces for the multifunctional control of a transhumeral prosthesis by patients who have undergone targeted muscle-reinnervation surgery, in long-term electroencephalography, and in simultaneous electroencephalography and structural and functional magnetic resonance imaging.

Original languageEnglish (US)
Pages (from-to)194-205
Number of pages12
JournalNature biomedical engineering
Volume3
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Prosthetics
Magnetic resonance imaging
Skin
Electroencephalography
Equipment and Supplies
Monitoring
Magnetic resonance
Eddy currents
Mountings
Surgery
Interfaces (computer)
Magnetic Resonance Imaging
Muscle
Robotics
Computer systems
Health
Computer Systems
Imaging techniques
Physiologic Monitoring
Scalp

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring. / Tian, Limei; Zimmerman, Benjamin; Akhtar, Aadeel; Yu, Ki Jun; Moore, Matthew; Wu, Jian; Larsen, Ryan J.; Lee, Jung Woo; Li, Jinghua; Liu, Yuhao; Metzger, Brian; Qu, Subing; Guo, Xiaogang; Mathewson, Kyle E.; Fan, Jonathan A.; Cornman, Jesse; Fatina, Michael; Xie, Zhaoqian; Ma, Yinji; Zhang, Jue; Zhang, Yihui; Dolcos, Florin; Fabiani, Monica; Gratton, Gabriele; Bretl, Timothy Wolfe; Hargrove, Levi J.; Braun, Paul V; Huang, Yonggang; Rogers, John A.

In: Nature biomedical engineering, Vol. 3, No. 3, 01.03.2019, p. 194-205.

Research output: Contribution to journalArticle

Tian, L, Zimmerman, B, Akhtar, A, Yu, KJ, Moore, M, Wu, J, Larsen, RJ, Lee, JW, Li, J, Liu, Y, Metzger, B, Qu, S, Guo, X, Mathewson, KE, Fan, JA, Cornman, J, Fatina, M, Xie, Z, Ma, Y, Zhang, J, Zhang, Y, Dolcos, F, Fabiani, M, Gratton, G, Bretl, TW, Hargrove, LJ, Braun, PV, Huang, Y & Rogers, JA 2019, 'Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring', Nature biomedical engineering, vol. 3, no. 3, pp. 194-205. https://doi.org/10.1038/s41551-019-0347-x
Tian, Limei ; Zimmerman, Benjamin ; Akhtar, Aadeel ; Yu, Ki Jun ; Moore, Matthew ; Wu, Jian ; Larsen, Ryan J. ; Lee, Jung Woo ; Li, Jinghua ; Liu, Yuhao ; Metzger, Brian ; Qu, Subing ; Guo, Xiaogang ; Mathewson, Kyle E. ; Fan, Jonathan A. ; Cornman, Jesse ; Fatina, Michael ; Xie, Zhaoqian ; Ma, Yinji ; Zhang, Jue ; Zhang, Yihui ; Dolcos, Florin ; Fabiani, Monica ; Gratton, Gabriele ; Bretl, Timothy Wolfe ; Hargrove, Levi J. ; Braun, Paul V ; Huang, Yonggang ; Rogers, John A. / Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring. In: Nature biomedical engineering. 2019 ; Vol. 3, No. 3. pp. 194-205.
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