Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle

Koyal Garg, Ziad S Mahmassani, Svyatoslav Dvoretskiy, M Carmen Valero, Heather D Huntsman, Samuel Lapp, Yu-Fu Wu, M S Stephen D Hauschka, Dean J Burkin, Marni D Boppart

Research output: Contribution to journalArticlepeer-review

Abstract

Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for two weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI + nuclei in aged muscle in response to MTE. LM-111 reduced CD11b + immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.

Original languageEnglish (US)
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
DOIs
StateE-pub ahead of print - Dec 7 2020

Fingerprint Dive into the research topics of 'Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle'. Together they form a unique fingerprint.

Cite this