Abstract
Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.
Original language | English (US) |
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Pages (from-to) | 586-590 |
Number of pages | 5 |
Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
Volume | 76 |
Issue number | 4 |
Early online date | Dec 7 2020 |
DOIs | |
State | Published - Apr 1 2021 |
Keywords
- Aging
- Chronic mechanical loading
- Extracellular matrix
- Hypertrophy
- Integrin
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Aging