Laminar flow based microreactor for efficient regeneration of nicotinamide cofactors for biocatalysis

S. K. Yoon, E. R. Choban, C. Kane, T. Tzedakis, Paul J A Kenis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a microreactor-based cofactor regeneration method that exploits the microfluidic phenomenon of laminar flow: A reactant stream and a buffer stream are introduced in a microchannel and continue to flow side by side without turbulent mixing between two electrodes that cover opposing channel walls. Adjustment of the flow rate ratio of the two streams in laminar flow enables focusing of the reactant stream closely to the cathode, thereby reversing a normally unfavorable reaction equilibrium essential for cofactor regeneration.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1431-1433
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • Biocatalysis
  • Cofactor regeneration
  • Laminar flow
  • Microfluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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