Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

Bas van Steensel, Andrew S. Belmont

Research output: Contribution to journalReview article

Abstract

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

Original languageEnglish (US)
Pages (from-to)780-791
Number of pages12
JournalCell
Volume169
Issue number5
DOIs
StatePublished - May 18 2017

Fingerprint

Nuclear Lamina
Heterochromatin
Chromosomes
Gene expression
Chromatin
Genes
Cells
Cell Nucleus

Keywords

  • LADs
  • chromosome architecture
  • gene repression
  • heterochromatin
  • lamina-associated domains
  • nuclear architecture

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lamina-Associated Domains : Links with Chromosome Architecture, Heterochromatin, and Gene Repression. / van Steensel, Bas; Belmont, Andrew S.

In: Cell, Vol. 169, No. 5, 18.05.2017, p. 780-791.

Research output: Contribution to journalReview article

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