Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals

Joseph A. Kmiecik, Carl D. Gregory, Zhi-Pei Liang, Paul C. Lauterbur, M. Joan Dawson

Research output: Contribution to journalArticlepeer-review

Abstract

Quantitative magnetic resonance imaging of lactate using a zero- quantum/double-quantum filter and generalized spectral localization by imaging (GSLIM) was applied to a model of unilateral stroke in gerbil brain. GSLIM lactate images at 4T clearly reveal elevated concentrations of lactate in the ischemic compared with the normal hemisphere 100-175 minutes after unilateral carotid ligation. These results indicate that the technique is capable of studies of brain infarcts, and that application to human ischemic pathology in brain and other tissues may be possible.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume9
Issue number4
DOIs
StatePublished - Apr 1999

Keywords

  • Brain
  • Gerbil
  • GSLIM
  • Lactate
  • MRI
  • Stroke

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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