TY - JOUR
T1 - Laboratory measures of hemostasis and fibrinolysis after intravenous administration of E-aminocaproic acid in clinically normal horses and ponies
AU - Heidmann, Peter
AU - Tornquist, Susan J.
AU - Qu, Annie
AU - Cebra, Christopher K.
PY - 2005/2
Y1 - 2005/2
N2 - Objective - To determine whether E-aminocaproic acid (EACA) administered IV affects hemostasis and fibrinolysis in clinically normal horses and ponies. Animals - 20 clinically normal adult horses and ponies. Procedures - Blood samples were collected 24 hours before (baseline) and 1 and 5 hours after IV administration of a low dose (30 mg/kg) or high dose (100 mg/kg) of EACA. Platelet count, fibrinogen concentration, prothrombin time, partial thromboplastin time (PTT), D-dimer concentration, α2-antiplasmin activity, and thrombin-antithrombin complex concentration were measured. Values at 1 and 5 hours were compared with baseline values. Results - 1 hour after administration of a low dose of EACA, mean fibrinogen concentration was significantly lower than baseline concentration. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a low dose of EACA. One hour after administration of 100 mg of EACA/kg, mean α2-antiplasmin activity was significantly higher than baseline activity. Mean fibrinogen concentration was significantly lower than baseline concentration 1 and 5 hours after administration of a high dose of EACA. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a high dose of EACA. Conclusions and Clinical Relevance - IV administration of 30 and 100mg of EACA/kg to clinically normal horses significantly modified some laboratory measures of hemostasis, consistent with its known antifibrinolytic effects. Although enhanced clot maintenance and diminished bleeding were not directly assessed, the clinical use of EACA may benefit some patients.
AB - Objective - To determine whether E-aminocaproic acid (EACA) administered IV affects hemostasis and fibrinolysis in clinically normal horses and ponies. Animals - 20 clinically normal adult horses and ponies. Procedures - Blood samples were collected 24 hours before (baseline) and 1 and 5 hours after IV administration of a low dose (30 mg/kg) or high dose (100 mg/kg) of EACA. Platelet count, fibrinogen concentration, prothrombin time, partial thromboplastin time (PTT), D-dimer concentration, α2-antiplasmin activity, and thrombin-antithrombin complex concentration were measured. Values at 1 and 5 hours were compared with baseline values. Results - 1 hour after administration of a low dose of EACA, mean fibrinogen concentration was significantly lower than baseline concentration. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a low dose of EACA. One hour after administration of 100 mg of EACA/kg, mean α2-antiplasmin activity was significantly higher than baseline activity. Mean fibrinogen concentration was significantly lower than baseline concentration 1 and 5 hours after administration of a high dose of EACA. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a high dose of EACA. Conclusions and Clinical Relevance - IV administration of 30 and 100mg of EACA/kg to clinically normal horses significantly modified some laboratory measures of hemostasis, consistent with its known antifibrinolytic effects. Although enhanced clot maintenance and diminished bleeding were not directly assessed, the clinical use of EACA may benefit some patients.
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U2 - 10.2460/ajvr.2005.66.313
DO - 10.2460/ajvr.2005.66.313
M3 - Article
C2 - 15757133
AN - SCOPUS:14844292572
SN - 0002-9645
VL - 66
SP - 313
EP - 318
JO - American journal of veterinary research
JF - American journal of veterinary research
IS - 2
ER -