TY - GEN
T1 - Label-free tomography of strongly scattering specimens
AU - Popescu, Gabriel
N1 - Publisher Copyright:
© OSA 2017.
PY - 2017
Y1 - 2017
N2 - Many specimens of interest, embryos, brain slices, organoids, are thick and optically inhomogeneous, which results in strong multiple scattering and low-contrast imaging. We developed GLIM as a novel label-free imaging method with applicability from nanoscale topographic structures to 2-300-micron thick tissues. Due to its interferometric principle that maintains equal power in the two interfering fields, GLIM is able to reject much of the multiple scattering background and generate high contrast interference. We present its principle and illustrate the performance with imaging nano pillars, cells, and embryos.
AB - Many specimens of interest, embryos, brain slices, organoids, are thick and optically inhomogeneous, which results in strong multiple scattering and low-contrast imaging. We developed GLIM as a novel label-free imaging method with applicability from nanoscale topographic structures to 2-300-micron thick tissues. Due to its interferometric principle that maintains equal power in the two interfering fields, GLIM is able to reject much of the multiple scattering background and generate high contrast interference. We present its principle and illustrate the performance with imaging nano pillars, cells, and embryos.
UR - http://www.scopus.com/inward/record.url?scp=85026326432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026326432&partnerID=8YFLogxK
U2 - 10.1364/DH.2017.Tu2A.1
DO - 10.1364/DH.2017.Tu2A.1
M3 - Conference contribution
AN - SCOPUS:85026326432
SN - 9781943580286
T3 - Optics InfoBase Conference Papers
BT - Digital Holography and Three-Dimensional Imaging, DH 2017
PB - Optica Publishing Group (formerly OSA)
T2 - Digital Holography and Three-Dimensional Imaging, DH 2017
Y2 - 29 May 2017 through 1 June 2017
ER -