Label-free intravital optical imaging is an emergent visualization tool that is not only useful for basic biological research, but also for preclinical research with potential translational clinical applications. The complete absence of exogenous labeling or genetic alterations avoids plausible harmful perturbation to biological processes and the pristine physiological environment, as the endogenous biomolecules enable intrinsic imaging contrasts to interrogate various live multicellular organisms of interest. This tool has evolved from single-modality, single-photon imaging into multimodal multiphoton imaging, in order to gain different contrasts simultaneously during imaging sessions, and permit long-term time-lapse studies that have begun to spawn more diverse applications.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages20
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Clinical application
  • Intravital imaging
  • Label-free imaging
  • Multimodal imaging
  • Multiphoton imaging
  • Preclinical research

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Label-Free Multimodal Multiphoton Intravital Imaging'. Together they form a unique fingerprint.

Cite this