Label free analyte detection by electronic desalting and field effect transistors

Rashid Bashir; Carlos Eduardo Duarte Guevara; Bobby Reddy Jr; Vikhram Vilasur Swaminathan; Eric M Salm

Label free analyte detection by electronic desalting and field effect transistors

Rashid Bashir (Inventor), Carlos Eduardo Duarte Guevara (Inventor), Bobby Reddy Jr (Inventor), Vikhram Vilasur Swaminathan (Inventor), Eric M Salm (Inventor)

Research output: Patent

Abstract

Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

Original language	English (US)
U.S. patent number	10527579
Filing date	3/27/15
State	Published - Jan 7 2020

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title = "Label free analyte detection by electronic desalting and field effect transistors",

abstract = "Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.",

author = "Rashid Bashir and Guevara, {Carlos Eduardo Duarte} and {Reddy Jr}, Bobby and {Vilasur Swaminathan}, Vikhram and Salm, {Eric M}",

note = "This invention was made with government support under R01CA120003 awarded by the National Institutes of Health, and EEC-0425626 awarded by the National Science Foundation. The government has certain rights in the invention.; 10527579",

year = "2020",

month = jan,

day = "7",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - Label free analyte detection by electronic desalting and field effect transistors

AU - Bashir, Rashid

AU - Guevara, Carlos Eduardo Duarte

AU - Reddy Jr, Bobby

AU - Vilasur Swaminathan, Vikhram

AU - Salm, Eric M

N1 - This invention was made with government support under R01CA120003 awarded by the National Institutes of Health, and EEC-0425626 awarded by the National Science Foundation. The government has certain rights in the invention.

PY - 2020/1/7

Y1 - 2020/1/7

N2 - Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

AB - Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

M3 - Patent

M1 - 10527579

Y2 - 2015/03/27

ER -

Label free analyte detection by electronic desalting and field effect transistors

Abstract

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