Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform

Charles Blatti, Amin Emad, Matthew J. Berry, Lisa Gatzke, Milt Epstein, Daniel Lanier, Pramod Rizal, Jing Ge, Xiaoxia Liao, Omar Sobh, Mike Lambert, Corey S. Post, Jinfeng Xiao, Peter Groves, Aidan T. Epstein, Xi Chen, Subhashini Srinivasan, Erik Lehnert, Krishna R. Kalari, Liewei WangRichard M. Weinshilboum, Jun S. Song, C. Victor Jongeneel, Jiawei Han, Umberto Ravaioli, Nahil Sobh, Colleen B. Bushell, Saurabh Sinha

Research output: Contribution to journalArticlepeer-review


We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis. The system specializes in “knowledge-guided” data mining and machine learning algorithms, in which user-provided data are analyzed in light of prior information about genes, aggregated from numerous knowledge bases and encoded in a massive “Knowledge Network.” KnowEnG adheres to “FAIR” principles (findable, accessible, interoperable, and reuseable): its tools are easily portable to diverse computing environments, run on the cloud for scalable and cost-effective execution, and are interoperable with other computing platforms. The analysis tools are made available through multiple access modes, including a web portal with specialized visualization modules. We demonstrate the KnowEnG system’s potential value in democratization of advanced tools for the modern genomics era through several case studies that use its tools to recreate and expand upon the published analysis of cancer data sets.

Original languageEnglish (US)
Article numbere3000583
JournalPLoS biology
Issue number1
StatePublished - 2020

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences


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