In dynamic covalent synthesis, kinetic traps are perceived as disadvantageous, hindering the system from reaching its thermodynamic equilibrium. Here we present the near-quantitative preparation of tetrahedral cages from simple tritopic precursors using alkyne metathesis. While the cages are the presumed thermodynamic sink, we experimentally demonstrate that the products no longer exchange their vertices once they have formed. The example reported here illustrates that kinetically trapped products may facilitate high yields of complex products from dynamic covalent synthesis.

Original languageEnglish (US)
Pages (from-to)2182-2185
Number of pages4
JournalJournal of the American Chemical Society
Issue number7
StatePublished - Mar 2 2016

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Kinetically Trapped Tetrahedral Cages via Alkyne Metathesis'. Together they form a unique fingerprint.

Cite this