TY - JOUR
T1 - Joint association between accelerometry-measured daily combination of time spent in physical activity, sedentary behaviour and sleep and all-cause mortality
T2 - A pooled analysis of six prospective cohorts using compositional analysis
AU - Chastin, Sebastien
AU - McGregor, Duncan
AU - Palarea-Albaladejo, Javier
AU - Diaz, Keith M.
AU - Hagströmer, Maria
AU - Hallal, Pedro Curi
AU - Van Hees, Vincent T.
AU - Hooker, Steven
AU - Howard, Virginia J.
AU - Lee, I. Min
AU - Von Rosen, Philip
AU - Sabia, Séverine
AU - Shiroma, Eric J.
AU - Yerramalla, Manasa S.
AU - Dall, Philippa
N1 - Funding Information:
Funding This work was supported by the Scottish Government’s Rural and Environment Science and Analytical Services Division (to DM and JPA) and the Spanish Ministry of Science, Innovation and Universities (CODAMET RTI2018-095518-B-C21, 2019-2021) (to JPA). The ABC study was supported by Stockholm County Council, Swedish National Centre for Research in Sports, and project ALPHA, which received funding from the European Union in the framework of the Public Health Programme and Folksam Research Foundation, Sweden (to MH and PvR). The REGARDS study was supported by a cooperative agreement U01 NS041588 cofunded by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Service. Additional funding was provided by an investigator-initiated grant R01-NS061846 from the NINDS/NIH (to SH) and an unrestricted research grant from The Coca-Cola Company. The Whitehall II study was supported by grants from the UK Medical Research Council (K013351, R024227, S011676); the British Heart Foundation (PG/11/63/29011 and RG/13/2/30098); the British Health and Safety Executive; the British Department of Health; the National Heart, Lung, and Blood Institute (R01HL036310); the NIA, NIH (R01AG056477, R01AG034454); and the Economic and Social Research Council (ES/J023299/1). MSY and SS were supported by the French National Research Agency (ANR-19-CE36-0004-01). The Women’s Health Study was supported by the NIH grants: CA154647, CA047988, CA182913, HL043851, HL080467 and HL099355 (to EJS and IML).
Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Objective To examine the joint associations of daily time spent in different intensities of physical activity, sedentary behaviour and sleep with all-cause mortality. Methods Federated pooled analysis of six prospective cohorts with device-measured time spent in different intensities of physical activity, sedentary behaviour and sleep following a standardised compositional Cox regression analysis. Participants 130 239 people from general population samples of adults (average age 54 years) from the UK, USA and Sweden. Main outcome All-cause mortality (follow-up 4.3-14.5 years). Results Studies using wrist and hip accelerometer provided statistically different results (I 2 =92.2%, Q-test p<0.001). There was no association between duration of sleep and all-cause mortality, HR=0.96 (95% CI 0.67 to 1.12). The proportion of time spent in moderate to vigorous physical activity was significantly associated with lower risk of all-cause mortality (HR=0.63 (95% CI 0.55 to 0.71) wrist; HR=0.93 (95% CI 0.87 to 0.98) hip). A significant association for the ratio of time spent in light physical activity and sedentary time was only found in hip accelerometer-based studies (HR=0.5, 95% CI 0.42 to 0.62). In studies based on hip accelerometer, the association between moderate to vigorous physical activity and mortality was modified by the balance of time spent in light physical activity and sedentary time. Conclusion This federated analysis shows a joint dose-response association between the daily balance of time spent in physical activity of different intensities and sedentary behaviour with all-cause mortality, while sleep duration does not appear to be significant. The strongest association is with time spent in moderate to vigorous physical activity, but it is modified by the balance of time spent in light physical activity relative to sedentary behaviour.
AB - Objective To examine the joint associations of daily time spent in different intensities of physical activity, sedentary behaviour and sleep with all-cause mortality. Methods Federated pooled analysis of six prospective cohorts with device-measured time spent in different intensities of physical activity, sedentary behaviour and sleep following a standardised compositional Cox regression analysis. Participants 130 239 people from general population samples of adults (average age 54 years) from the UK, USA and Sweden. Main outcome All-cause mortality (follow-up 4.3-14.5 years). Results Studies using wrist and hip accelerometer provided statistically different results (I 2 =92.2%, Q-test p<0.001). There was no association between duration of sleep and all-cause mortality, HR=0.96 (95% CI 0.67 to 1.12). The proportion of time spent in moderate to vigorous physical activity was significantly associated with lower risk of all-cause mortality (HR=0.63 (95% CI 0.55 to 0.71) wrist; HR=0.93 (95% CI 0.87 to 0.98) hip). A significant association for the ratio of time spent in light physical activity and sedentary time was only found in hip accelerometer-based studies (HR=0.5, 95% CI 0.42 to 0.62). In studies based on hip accelerometer, the association between moderate to vigorous physical activity and mortality was modified by the balance of time spent in light physical activity and sedentary time. Conclusion This federated analysis shows a joint dose-response association between the daily balance of time spent in physical activity of different intensities and sedentary behaviour with all-cause mortality, while sleep duration does not appear to be significant. The strongest association is with time spent in moderate to vigorous physical activity, but it is modified by the balance of time spent in light physical activity relative to sedentary behaviour.
KW - health
KW - physical activity
KW - sleep
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U2 - 10.1136/bjsports-2020-102345
DO - 10.1136/bjsports-2020-102345
M3 - Article
C2 - 34006506
AN - SCOPUS:85106177909
SN - 0306-3674
VL - 55
SP - 1277
EP - 1285
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 22
ER -