Jekyll & Hyde: Evolution of a Superfamily

Susan A. Martinis, Yan Ling Joy Pang

Research output: Contribution to journalShort survey

Abstract

Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].

Original languageEnglish (US)
Pages (from-to)1307-1308
Number of pages2
JournalChemistry and Biology
Volume14
Issue number12
DOIs
StatePublished - Dec 26 2007

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Tyrosine-tRNA Ligase
Cell signaling
Amino Acyl-tRNA Synthetases
Aminoacylation
Engineers
Mutation
Proteins

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Jekyll & Hyde : Evolution of a Superfamily. / Martinis, Susan A.; Joy Pang, Yan Ling.

In: Chemistry and Biology, Vol. 14, No. 12, 26.12.2007, p. 1307-1308.

Research output: Contribution to journalShort survey

Martinis, Susan A. ; Joy Pang, Yan Ling. / Jekyll & Hyde : Evolution of a Superfamily. In: Chemistry and Biology. 2007 ; Vol. 14, No. 12. pp. 1307-1308.
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