Jekyll & Hyde: Evolution of a Superfamily

Susan A. Martinis, Yan Ling Joy Pang

Research output: Contribution to journalShort surveypeer-review


Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].

Original languageEnglish (US)
Pages (from-to)1307-1308
Number of pages2
JournalChemistry and Biology
Issue number12
StatePublished - Dec 26 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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