Jekyll & Hyde: Evolution of a Superfamily

Susan A. Martinis; Yan Ling Joy Pang

doi:10.1016/j.chembiol.2007.12.001

Jekyll & Hyde: Evolution of a Superfamily

Research output: Contribution to journal › Short survey › peer-review

Abstract

Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].

Original language	English (US)
Pages (from-to)	1307-1308
Number of pages	2
Journal	Chemistry and Biology
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.chembiol.2007.12.001
State	Published - Dec 26 2007

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2007.12.001

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title = "Jekyll & Hyde: Evolution of a Superfamily",

abstract = "Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].",

author = "Martinis, {Susan A.} and {Joy Pang}, {Yan Ling}",

year = "2007",

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AU - Martinis, Susan A.

AU - Joy Pang, Yan Ling

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AB - Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].

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Jekyll & Hyde: Evolution of a Superfamily

Abstract

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