Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus

Su Zhang; Robert E. Wickesberg; Donata Oertel

doi:10.1016/0006-8993(89)91043-3

Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus

Su Zhang, Robert E. Wickesberg, Donata Oertel

Research output: Contribution to journal › Article › peer-review

Abstract

Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.

Original language	English (US)
Pages (from-to)	194-197
Number of pages	4
Journal	Brain Research
Volume	501
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91043-3
State	Published - Oct 30 1989
Externally published	Yes

Keywords

Bilirubin
Cochlear nucleus
Gunn rat
Hearing
Jaundice

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Online availability

10.1016/0006-8993(89)91043-3

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title = "Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus",

abstract = "Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.",

keywords = "Bilirubin, Cochlear nucleus, Gunn rat, Hearing, Jaundice",

author = "Su Zhang and Wickesberg, {Robert E.} and Donata Oertel",

note = "Funding Information: We thankD rs. Brugge,S hapiro,O dell and Whit-Ion for helpfuls uggestionasn dc riticismsT. he work was supportedb y NIH grants1 7590a nd 12732.",

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AU - Wickesberg, Robert E.

AU - Oertel, Donata

N1 - Funding Information: We thankD rs. Brugge,S hapiro,O dell and Whit-Ion for helpfuls uggestionasn dc riticismsT. he work was supportedb y NIH grants1 7590a nd 12732.

PY - 1989/10/30

Y1 - 1989/10/30

N2 - Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.

AB - Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.

KW - Bilirubin

KW - Cochlear nucleus

KW - Gunn rat

KW - Hearing

KW - Jaundice

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Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus

Abstract

Keywords

ASJC Scopus subject areas

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