Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus

Su Zhang, Robert E. Wickesberg, Donata Oertel

Research output: Contribution to journalArticlepeer-review

Abstract

Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalBrain Research
Volume501
Issue number1
DOIs
StatePublished - Oct 30 1989
Externally publishedYes

Keywords

  • Bilirubin
  • Cochlear nucleus
  • Gunn rat
  • Hearing
  • Jaundice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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