Iterative image reconstruction in elastic inhomogenous media with application to transcranial photoacoustic tomography

Joemini Poudel, Thomas P. Matthews, Kenji Mitsuhashi, Alejandro Garcia-Uribe, Lihong V. Wang, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The PACT reconstruction problem corresponds to a time-domain inverse source problem, where the initial pressure distribution is recovered from the measurements recorded on an aperture outside the support of the source. A major challenge in transcranial PACT brain imaging is to compensate for aberrations in the measured data due to the propagation of the photoacoustic wavefields through the skull. To properly account for these effects, a wave equation-based inversion method should be employed that can model the heterogeneous elastic properties of the medium. In this study, an iterative image reconstruction method for 3D transcranial PACT is developed based on the elastic wave equation. To accomplish this, a forward model based on a finite-difference time-domain discretization of the elastic wave equation is established. Subsequently, gradient-based methods are employed for computing penalized least squares estimates of the initial source distribution that produced the measured photoacoustic data. The developed reconstruction algorithm is validated and investigated through computer-simulation studies.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2017
Subtitle of host publicationUltrasonic Imaging and Tomography
EditorsNeb Duric, Neb Duric, Brecht Heyde
PublisherSPIE
ISBN (Electronic)9781510607231
DOIs
StatePublished - 2017
Externally publishedYes
EventMedical Imaging 2017: Ultrasonic Imaging and Tomography - Orlando, United States
Duration: Feb 15 2017Feb 16 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10139
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2017: Ultrasonic Imaging and Tomography
Country/TerritoryUnited States
CityOrlando
Period2/15/172/16/17

Keywords

  • Photoacoustic computed tomography,image reconstruction
  • elastic wave equation
  • transcranial imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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