Abstract
Methyllanthionine (MeLan) containing macrocycles are key structural features of lanthipeptides. They are formed typically by anti-elimination of L-Thr residues followed by cyclization of L-Cys residues onto the (Z)-dehydrobutyrine (Dhb) intermediates. In this report we demonstrate that the biosynthesis of lanthipeptides containing the D-allo-L-MeLan macrocycle such as the morphogenetic lanthipeptide SapT proceeds through (E)-Dhb intermediates formed by net syn-elimination of L-Thr.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1165-1168 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 59 |
| Issue number | 9 |
| Early online date | Dec 14 2022 |
| DOIs | |
| State | Published - Dec 14 2022 |