@article{750bed3072014ed3ac7f9c1767759a60,
title = "Isolation of 2 (Antho-RPamide II), a novel, biologically active neuropeptide from sea anemones",
abstract = "Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide 2 (Antho-RPamide II) from extracts of the sea anemone Anthopleura elegantissima. Addition of low concentrations of Antho-RPamide II to a tentacle preparation of sea anemones inhibited the spontaneous, rhythmic contractions, suggesting that the peptide is a neurotransmitter or neuromodulator.",
keywords = "Coelenterate, Mass spectrometry, Neurohormone, Neurotransmitter, Peptide structure",
author = "Klaus Carstensen and McFarlane, {Ian D.} and Rinehart, {Kenneth L.} and Diane Hudman and Furong Sun and Grimmelikhuijzen, {Cornelis J.P.}",
note = "Funding Information: We thank Susanne Raabe and Dagmar Boshold for typing the manuscript, and the Bundesministerium f'dr Forschung und Technologie, the Deutsche Forschungsgemeinschafi (Gr 762/7-3), Fonds der Chemischen lndustrie (to C.J.P.G.), NATO (Collaborative Research Grant to C.J.P.G.), Ciba-Geigy (Award for Cooperation in Europe to I.D.M.), and the National Institute of General Medical Sciences (GM 27029, to K.L.R.) for financial support. A part of this article is based on a doctoral study by K.C. in the Faculty of Biology, University of Hamburg.",
year = "1993",
doi = "10.1016/0196-9781(93)90020-H",
language = "English (US)",
volume = "14",
pages = "131--135",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "2",
}