TY - JOUR
T1 - Isolation and structures of microcystins from a cyanobacterial water bloom (Finland)
AU - Namikoshi, Michio
AU - Sivonen, Kaarina
AU - Evans, William R.
AU - Sun, Furong
AU - Carmichael, Wayne W.
AU - Rinehart, Kenneth L.
N1 - Funding Information:
latter grant to W.W.C. Research at the University of Helsinki was supported by a grant from the Academy of Finland. We thank Mr JuHANi Stamaus for collecting the bloom material and Ms TAINA LuouA for help in concentration of collected material .
Funding Information:
Acknowledgements-This study was supported in part by grants from the National Institutes of General Medical Sciences (GM 27029) and of Allergy and Infectious Diseases (Al 04769) to K .L .R. and by a subcontract from the
PY - 1992/11
Y1 - 1992/11
N2 - A hepatotoxic cyanobacterial (blue-green algal) water bloom was collected from a constructed water reservoir in Finland. The water bloom contained two cyanobacterial species, Microcystis aeruginosa and Aphanizomenon flos-aquae. Two hepatotoxins, 1 and 2, were isolated from extracts of lyophilized cells. The structures of 1 and 2 were assigned based upon their amino acid analyses on a Waters Pico Tag HPLC system and a chiral GC capillary column (Chirasil Val III), fast atom bombardment mass spectrometry (FABMS), high resolution FABMS, and tandem FABMS data. Toxin 1 was identical to a previously reported compound, [d-Asp3]microcystin-RR. Toxin 2 was new and was assigned the structure [d-Asp3]microcystin-YR.
AB - A hepatotoxic cyanobacterial (blue-green algal) water bloom was collected from a constructed water reservoir in Finland. The water bloom contained two cyanobacterial species, Microcystis aeruginosa and Aphanizomenon flos-aquae. Two hepatotoxins, 1 and 2, were isolated from extracts of lyophilized cells. The structures of 1 and 2 were assigned based upon their amino acid analyses on a Waters Pico Tag HPLC system and a chiral GC capillary column (Chirasil Val III), fast atom bombardment mass spectrometry (FABMS), high resolution FABMS, and tandem FABMS data. Toxin 1 was identical to a previously reported compound, [d-Asp3]microcystin-RR. Toxin 2 was new and was assigned the structure [d-Asp3]microcystin-YR.
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U2 - 10.1016/0041-0101(92)90523-8
DO - 10.1016/0041-0101(92)90523-8
M3 - Article
C2 - 1485342
AN - SCOPUS:0026480619
SN - 0041-0101
VL - 30
SP - 1473
EP - 1479
JO - Toxicon
JF - Toxicon
IS - 11
ER -