Ischemia/reperfusion: A potential cause for tissue necrosis

William J. Ennis, Timothy J. Koh, Norifumi Urao, Yih-Kuen Jan, Audrey Sui, Kate Brown, Martin Borhani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There are many clinical conditions which are either caused or exacerbated by ischemia/reperfusion injury (IRI). While the wound care community has expanded its understanding of the cellular and molecular mechanisms surrounding the healing process, research involving the microcirculation and its impact on healing has been limited. Reasons for this include but are not limited to an emphasis on the diagnosis and treatment of macrovascular disorders, the absence of surgical options directed at the microcirculation, and a limited number of pharmacologic and/or modality–based therapeutic options. There are also few well–accepted methods for the diagnosis of adequate tissue perfusion, and those that are available have not been transferred well from the lab to the bedside. Clinicians are therefore left with their experience and macro–level observations as a primary means for gauging successful outcomes. Once macro–level changes are apparent, however, it is often too late to intervene therapeutically thus limiting the potential efficacy of treatment options. In this chapter, we will describe the basic anatomy and physiology of the microcirculation and then focus on the consequences, both positive and negative, of the restoration of flow to ischemic tissue. New potentially useful diagnostic methods for assessing tissue perfusion and microcirculation will be presented along with a clinical case that will bring these didactic concepts into a real–world clinical setting. Finally, new treatment options that may mitigate the effects of ischemic reperfusion injury will be discussed.

Original languageEnglish (US)
Title of host publicationSkin Necrosis
PublisherSpringer-Verlag Vienna
Pages9-17
Number of pages9
ISBN (Electronic)9783709112410
ISBN (Print)9783709112403
DOIs
StatePublished - Jan 1 2015

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Microcirculation
Reperfusion
Necrosis
Ischemia
Reperfusion Injury
Perfusion
Anatomy
Wounds and Injuries
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)

Cite this

Ennis, W. J., Koh, T. J., Urao, N., Jan, Y-K., Sui, A., Brown, K., & Borhani, M. (2015). Ischemia/reperfusion: A potential cause for tissue necrosis. In Skin Necrosis (pp. 9-17). Springer-Verlag Vienna. https://doi.org/10.1007/978-3-7091-1241-0_2

Ischemia/reperfusion : A potential cause for tissue necrosis. / Ennis, William J.; Koh, Timothy J.; Urao, Norifumi; Jan, Yih-Kuen; Sui, Audrey; Brown, Kate; Borhani, Martin.

Skin Necrosis. Springer-Verlag Vienna, 2015. p. 9-17.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ennis, WJ, Koh, TJ, Urao, N, Jan, Y-K, Sui, A, Brown, K & Borhani, M 2015, Ischemia/reperfusion: A potential cause for tissue necrosis. in Skin Necrosis. Springer-Verlag Vienna, pp. 9-17. https://doi.org/10.1007/978-3-7091-1241-0_2
Ennis WJ, Koh TJ, Urao N, Jan Y-K, Sui A, Brown K et al. Ischemia/reperfusion: A potential cause for tissue necrosis. In Skin Necrosis. Springer-Verlag Vienna. 2015. p. 9-17 https://doi.org/10.1007/978-3-7091-1241-0_2
Ennis, William J. ; Koh, Timothy J. ; Urao, Norifumi ; Jan, Yih-Kuen ; Sui, Audrey ; Brown, Kate ; Borhani, Martin. / Ischemia/reperfusion : A potential cause for tissue necrosis. Skin Necrosis. Springer-Verlag Vienna, 2015. pp. 9-17
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