Iron-catalyzed intramolecular allylic C-H amination

Shauna M. Paradine, M. Christina White

Research output: Contribution to journalArticlepeer-review


A highly selective C-H amination reaction under iron catalysis has been developed. This novel system, which employs an inexpensive, nontoxic [Fe IIIPc] catalyst (typically used as an industrial ink additive), displays a strong preference for allylic C-H amination over aziridination and all other C-H bond types (i.e., allylic > benzylic > ethereal > 3° > 2° ≫ 1°). Moreover, in polyolefinic substrates, the site selectivity can be controlled by the electronic and steric character of the allylic C-H bond. Although this reaction is shown to proceed via a stepwise mechanism, the stereoretentive nature of C-H amination for 3° aliphatic C-H bonds suggests a very rapid radical rebound step.

Original languageEnglish (US)
Pages (from-to)2036-2039
Number of pages4
JournalJournal of the American Chemical Society
Issue number4
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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