Iridium-catalyzed enantioselective polyene cyclization

Michael A. Schafroth, David Sarlah, Simon Krautwald, Erick M. Carreira

Research output: Contribution to journalArticlepeer-review


A highly enantioselective polycyclization method has been developed using the combination of Lewis acid activation with iridium-catalyzed allylic substitution. This strategy relies on direct use of branched, racemic allylic alcohols and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields and ≥99% ee.

Original languageEnglish (US)
Pages (from-to)20276-20278
Number of pages3
JournalJournal of the American Chemical Society
Issue number50
StatePublished - Dec 19 2012
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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