Iridium-catalyzed enantioselective allyl-alkene coupling

James Y. Hamilton, David Sarlah, Erick M. Carreira

Research output: Contribution to journalArticle

Abstract

The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.

Original languageEnglish (US)
Pages (from-to)3006-3009
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number8
DOIs
StatePublished - Feb 26 2014
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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