Ir gene regulation of T cell proliferation: requirement for Ia and antigen expression on the same accessory cell.

L. B. Schook, D. A. Campbell, J. E. Niederhuber

Research output: Contribution to journalArticle

Abstract

These results demonstrate that only splenic macrophages expressing both Ir products (function) and the antigen (GAT) were able to reconstitute the T cell response of cultures in which the splenic macrophage monolayer had been treated with appropriate anti I-A antibodies. This inhibition was not a result of induced suppression caused by anti-Ia treatment but rather a masking of Ia antigen which prevents the T cell receptor(s) from recognizing either the Ir gene product and specific antigen in complex or separately.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalAdvances in experimental medicine and biology
Volume155
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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