Ionic α-helical polypeptides toward nonviral gene delivery

Rujing Zhang; Ziyuan Song; Lichen Yin; Nan Zheng; Haoyu Tang; Hua Lu; Nathan P. Gabrielson; Yao Lin; Kyung Kim; Jianjun Cheng

doi:10.1002/wnan.1307

Ionic α-helical polypeptides toward nonviral gene delivery

Rujing Zhang, Ziyuan Song, Lichen Yin, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Yao Lin, Kyung Kim, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.

Original language	English (US)
Pages (from-to)	98-110
Number of pages	13
Journal	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/wnan.1307
State	Published - Jan 1 2015
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering

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10.1002/wnan.1307

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AU - Zhang, Rujing

AU - Song, Ziyuan

AU - Yin, Lichen

AU - Zheng, Nan

AU - Tang, Haoyu

AU - Lu, Hua

AU - Gabrielson, Nathan P.

AU - Lin, Yao

AU - Kim, Kyung

AU - Cheng, Jianjun

PY - 2015/1/1

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Ionic α-helical polypeptides toward nonviral gene delivery

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