Ionic α-helical polypeptides toward nonviral gene delivery

Rujing Zhang, Ziyuan Song, Lichen Yin, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Yao Lin, Kyung Kim, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review


The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.

Original languageEnglish (US)
Pages (from-to)98-110
Number of pages13
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering


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