The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.
|Original language||English (US)|
|Number of pages||13|
|Journal||Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biomedical Engineering