Iodohexestrols. I. Synthesis and Photoreactivity of Iodinated Hexestrol Derivatives

John A. Katzenellenbogen, Hansen M. Hsiung

Research output: Contribution to journalArticlepeer-review


The five possible ortho-iodinated hexestrols, containing from 1-4 iodines per molecule, have been synthesized as potential iodine-containing estrogenic ligands. After chromatographic separation and purification, each derivative has been fully characterized by spectroscopic methods. [3H]-3-Iodohexestrol, [131I]- and [125I]-3-iodohexestrol, and [125I]-3,5-diiodohexestrol have also been prepared. Photolysis of 3,5-diiodohexestrol in methanol results in rapid deiodination to 3-iodohexestrol; further reduction to hexestrol is slower. Photolysis of 3-iodohexestrol in benzene gives 3-phenylhexestrol.

Original languageEnglish (US)
Pages (from-to)1736-1741
Number of pages6
Issue number8
StatePublished - Apr 1 1975

ASJC Scopus subject areas

  • Biochemistry


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