Involvement of microRNAs in lung cancer biology and therapy

Xi Liu, Lorenzo F. Sempere, Yongli Guo, Murray Korc, Sakari Kauppinen, Sarah J. Freemantle, Ethan Dmitrovsky

Research output: Contribution to journalReview article

Abstract

MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. Expression profiles of specific miRNAs have improved cancer diagnosis and classification as well as provided prognostic information in many human cancers, including lung cancer. Tumor-suppressive and oncogenic miRNAs were uncovered in lung carcinogenesis. The biological functions of these miRNAs in lung cancer were validated recently in well-characterized cellular, murine transgenic as well as transplantable lung cancer models, and in human paired normal-malignant lung tissue banks and tissue arrays. Tumor-suppressive and oncogenic miRNAs that were identified in lung cancer will be reviewed here. Emphasis is placed on highlighting those functionally validated miRNAs that are not only biomarkers of lung carcinogenesis but also candidate pharmacologic targets. How these miRNA findings advance an understanding of lung cancer biology and how they could improve lung cancer therapy are discussed in this article.

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalTranslational Research
Volume157
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • ISH
  • LATS2
  • LNA
  • NSCLC
  • PP2A regulatory subunit B alpha isoform
  • PPP2R2A
  • RISC
  • RNA-induced silencing complex
  • SCLC
  • in situ hybridization
  • large tumor suppressor 2
  • locked nucleic acid
  • miRNAs
  • microRNAs
  • non-small cell lung cancer
  • pre-miRNA
  • precursor miRNA
  • pri-miRNAs
  • primary miRNAs
  • small cell lung cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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  • Cite this

    Liu, X., Sempere, L. F., Guo, Y., Korc, M., Kauppinen, S., Freemantle, S. J., & Dmitrovsky, E. (2011). Involvement of microRNAs in lung cancer biology and therapy. Translational Research, 157(4), 200-208. https://doi.org/10.1016/j.trsl.2011.01.001