The stereochemical course of the Lewis acidand fluoride ion-promoted aldol reaction has been studied with model 1. Cyclizations of 1 show a modest preference for reaction via an antiperiplanar (open transition state) orientation of reactants in the presence of a wide range of Lewis acids and fluoride sources.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Organic Chemistry|
|State||Published - Feb 1 1994|
ASJC Scopus subject areas
- Organic Chemistry