@inproceedings{ced38f120d7e4f9dbef5782692a00e44,
title = "Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery",
abstract = "The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.",
keywords = "Drug delivery, High intensity focused ultrasound, Hyperthermia, Thermal mechanism",
author = "O'Neill, {Brian E.} and Li, {King C} and Victor Frenkel and Howard Vo and Mary Angstadt and Wood, {Bradford J.} and Quinn, {Timothy P.}",
year = "2007",
doi = "10.1109/ULTSYM.2007.16",
language = "English (US)",
isbn = "1424413834",
series = "Proceedings - IEEE Ultrasonics Symposium",
pages = "1--4",
booktitle = "2007 IEEE Ultrasonics Symposium Proceedings, IUS",
note = "2007 IEEE Ultrasonics Symposium, IUS ; Conference date: 28-10-2007 Through 31-10-2007",
}