Investigation of 1H MRS for quantification of hepatic triglyceride in lean and obese cats

M. H. Clark, R. Larsen, W. Lu, M. Hoenig

Research output: Contribution to journalArticle

Abstract

1H magnetic resonance spectroscopy (1H MRS) is the preferred technique for noninvasive quantification of hepatic triglyceride in humans. Domestic cats are subject to liver lipid accumulation, but MRS has not been investigated for quantification of liver fat in cats. The purpose of this project was to explore a technique for 1H MRS measurement of hepatic triglyceride in lean and obese cats. Hepatic 1H MRS was performed, using a 3T imaging unit and a single-voxel spin-echo spectroscopy sequence, on 6 lean (3.3-4.6kg) and 12 obese cats (5.2-9.8kg). Median liver fat percentages in lean and obese cats were 1.3% and 6.8%, respectively. Results are biologically plausible, based on chemical assay in a separate group of cats; however, full validation of the method is necessary before other conclusions can be drawn. This report should provide a foundation for the further development of spectroscopic techniques for studying hepatic lipid accumulation in cats.

Original languageEnglish (US)
Pages (from-to)678-680
Number of pages3
JournalResearch in Veterinary Science
Volume95
Issue number2
DOIs
StatePublished - Oct 1 2013

Keywords

  • Cats
  • H MRS
  • Liver
  • Spectroscopy
  • Triglyceride

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Investigation of <sup>1</sup>H MRS for quantification of hepatic triglyceride in lean and obese cats'. Together they form a unique fingerprint.

  • Cite this