Investigation of quantitative polychromatic X-ray phase-contrast tomography for tissue characterization

Cheng Ying Chou, Adam M. Zysk, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


At diagnostic X-ray energies, variations in the real component of the refractive index of tissues are several orders of magnitude larger than variations in the imaginary component, or equivalently, the X-ray attenuation coefficient. Consequently, X-ray phase-contrast imaging may permit the visualization of tissues that have identical, or very similar, X-ray absorption properties. Quantitative in-line phase-contrast tomography methods seek to reconstruct the three-dimensional (3D) complex X-ray refractive index distribution of tissue. Almost all existing image reconstruction algorithms for quantitative phase-contrast tomography make physical assumptions that are not consistent with benchtop or clinical implementations that employ an X-ray tube. Such assumptions include a monochromatic plane-wave X-ray beam that possesses perfect coherence properties. In this work, we implement and investigate a reconstruction theory for quantitative phase-contrast tomography that is suitable for use with polychromatic X- ay beams produced by a tube source. An image reconstruction algorithm is implemented that requires, as input data, two intensity measurements at each tomographic view that correspond to incident X-ray beams with distinct coherence properties. Computer-simulation studies that emulate polychromatic tube-based imaging conditions are conducted to assess the effectiveness of the reconstruction method for characterizing soft tissue structures.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
StatePublished - Jun 15 2009
Externally publishedYes
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2009: Physics of Medical Imaging
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Coherence
  • Polychromatic
  • Tissue characterization
  • X-ray phase-contrast imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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