Abstract
The development of catalytic, enantioselective halofunctionalizations of unactivated alkenes has made significant progress in recent years. However, the identification of generally applicable catalysts for wide range of substrates has yet to be realized. A detailed understanding of the reaction mechanism is essential to guide the formulation of a truly general catalyst. Herein, we present our investigations on the enantiodetermining step of a Lewis base catalyzed bromocycloetherification that provides important insights and design criteria.
| Original language | English (US) |
|---|---|
| Article number | st-2017-b0700-c |
| Pages (from-to) | 433-439 |
| Number of pages | 7 |
| Journal | Synlett |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 1 2018 |
Keywords
- Lewis base
- alkenes
- bromiranium ions
- bromocycloetherification
- halofunctionalization
- selenophosphoramides
ASJC Scopus subject areas
- Organic Chemistry