@article{a1bb8d5058eb4a5ba0950e5787902b52,
title = "Investigating brain d-serine: Advocacy for good practices",
abstract = "The last two decades have witnessed remarkable advance in our understanding the role of d-amino acids in the mammalian nervous system: from the unknown, to known molecules with unknown functions, to potential central players in health and disease. d-Amino acids have emerged as an important class of signaling molecules. In particular, the exploration of the roles of d-serine in brain physiopathology is a vibrant field that is growing at an accelerating pace. However, disentangling the functions of a chiral molecule in a complex chemical matrice as the brain requires specific measurement and detection methods but is also a challenging task as many molecular tools and models investigators are using can lead to confounded observations. Thus, study of d-amino acids demands accurate methodologies and specific controls, and these have often been lacking. Here we outline best practices for d-amino acid research, with a special emphasis on d-serine. We hope these concepts help move the field to greater rigor and reproducibility, allowing the field to advance.",
keywords = "NMDA receptors, analytical methods, d-Serine, glia, immunostainings, neurons, rescue experiments, serine racemase inhibitors",
author = "Mothet, {Jean Pierre} and Billard, {Jean Marie} and Loredano Pollegioni and Coyle, {Joseph T.} and Sweedler, {Jonathan V.}",
note = "Funding Information: JPM is supported by CNRS and by Fondation pour la Recherche Medicale team award (Equipe FRM DEQ20150331734). JMB is supported by INSERM and by Fondation France Alzheimer. LP is supported from Fondo di Ateneo per la Ricerca and by Fondazione Comunitaria del Varesotto, 2017. JTC received support from the National Institutes of Health grants R01MH05190 and P50MH0G0450. JVS is supported by the National Institute on Drug Abuse under Award No. P30 DA018310, and the National Institute of Neurological Disorders and Stroke under Award No. R01 NS031609. The funders had no role in the decision to publish or prepare the manuscript. Funding Information: Funding information JPM is supported by CNRS and by Fondation pour la Recherche Medicale team award (Equipe FRM DEQ20150331734). JMB is supported by INSERM and by Fondation France Alzheimer. LP is supported from Fondo di Ateneo per la Ricerca and by Fondazione Comunitaria del Varesotto, 2017. JTC received support from the National Institutes of Health grants R01MH05190 and P50MH0G0450. JVS is supported by the National Institute on Drug Abuse under Award No. P30 DA018310, and the National Institute of Neurological Disorders and Stroke under Award No. R01 NS031609. The funders had no role in the decision to publish or prepare the manuscript. Publisher Copyright: {\textcopyright} 2019 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd",
year = "2019",
month = may,
doi = "10.1111/apha.13257",
language = "English (US)",
volume = "226",
journal = "Acta Physiologica",
issn = "1748-1708",
number = "1",
}