Abstract
We report the first example of directed evolution of a P450 monooxygenase with inverted enantioselectivity for asymmetric biohydroxylation. The biohydroxylation product of the best mutant 1AF4A has an ee of 83% (R) compared to the wild type's ee of 43% (S).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5461-5463 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 46 |
| Issue number | 30 |
| DOIs | |
| State | Published - Aug 14 2010 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry