Inverse relationship of cotranslational translocation with the hydrophobic moment of the bovine preproparathyroid hormone signal sequence

Kwangseog Ahn, David Chen, Byron Kemper

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the dependence of transmembrane translocation on the hydrophobic moment of the hydrophobic core of the preproparathyroid hormone signal sequence, amino acids were switched to maximize or minimize the hydrophobic moment without changing the length or overall hydrophobicity of the core. As assayed in an in vitro translation system with microsomal membranes, the efficiency of translocation of these mutants was inversely related to the hydrophobic moment, indicating the hydrophobic moment or a related property may contribute to translocational activity.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalBBA - Molecular Cell Research
Volume1224
Issue number3
DOIs
StatePublished - Dec 30 1994

Keywords

  • Hydrophobic moment
  • Parathyroid hormone
  • Translocation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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