Intravenous iron given prior to pregnancy for restless legs syndrome is associated with remission of symptoms

Restless legs syndrome (RLS) is more common during pregnancy than in the general population, occurring at a 2-3 times higher prevalence. While iron, genetics, and central nervous system dopamine have been shown to play major roles in RLS unrelated to pregnancy, the etiology and treatment of RLS during pregnancy have not been adequately delineated. We describe a novel approach where a 23-year-old female was given intravenous iron prior to pregnancy, with complete remission of RLS symptoms until fi ve months postpartum. Factors other than iron status that may have infl uenced the course of remission and relapse were oral contraceptive use, antidepressant use, and a strong family history of RLS.