Intravenous anesthetic, propofol affects synaptic responses in cerebellar purkinje cells

Kwan Young Lee, Yujin Jang, Min Hee Lee, Young Im Kim, Sung Cherl Jung, Seung Yun Han, Se Hoon Kim, Hyung Seo Park, Dong Kwan Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Propofol is an intravenously administered anesthetic that enhances -aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated in movement disorders. The cerebellum is important for motor coordination and motor learning. The aim of the present study was to investigate the propofol effect on excitatory synaptic transmissions in cerebellar cortex. Methods: Excitatory postsynaptic currents by parallel fiber stimulation and complex spikes by climbing fiber stimulation were monitored in Purkinje cells of Wister rat cerebellar slice using whole-cell patch-clamp techniques. Results: Decay time, rise time and amplitude of excitatory postsynaptic currents at parallel fiber Purkinje cell synapses and area of complex spikes at climbing fiber Purkinje cell synapses were significantly increased by propofol administration. Conclusion: The detected changes of glutamatergic synaptic transmission in cerebellar Purkinje cell, which determine cerebellar motor output, could explain cerebellar mechanism of motor deficits induced by propofol.

Original languageEnglish (US)
Pages (from-to)176-183
Number of pages8
JournalClinical Psychopharmacology and Neuroscience
Volume16
Issue number2
DOIs
StatePublished - May 2018

Keywords

  • Anesthetics
  • Cerebellum
  • Propofol
  • Purkinje cells
  • Synaptic transmission

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

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