Abstract
We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM-OCT signal from the aorta samples specimens injected with targeted MSs. Representative magnetomotive signal (green) using targeted and non-targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. The development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques is reports. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM-OCT signal from the aorta samples specimens injected with targeted MSs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 109-116 |
| Number of pages | 8 |
| Journal | Journal of Biophotonics |
| Volume | 9 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 2016 |
Keywords
- Atherosclerosis
- Catheter
- Fatty streaks
- Magnetomotive
- Optical coherence tomography
- Protein microspheres
- αβ integrin
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- General Biochemistry, Genetics and Molecular Biology
- General Engineering
- General Physics and Astronomy