Intratumoral Heterogeneity of the Epigenome

Tali Mazor, Aleksandr Pankov, Jun S. Song, Joseph F. Costello

Research output: Contribution to journalReview articlepeer-review


Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may drive drug resistance, and the degree of epigenetic ITH at diagnosis may predict patient outcome. This perspective presents these current concepts and clinical implications of epigenetic ITH, and the experimental and computational techniques at the forefront of ITH exploration.

Original languageEnglish (US)
Pages (from-to)440-451
Number of pages12
JournalCancer Cell
Issue number4
StatePublished - Apr 11 2016

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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