Abstract
Five patients with clinically advanced subacute sclerosing panencephalitis (SSPE) were given human leukocyte interferon (IFN) by the lumbar route, 1 million IU every other day for a total of 30 days. Intrathecal IFN produced a meningeal inflammatory reaction in all patients and was associated with transient hemiparesis in 1. It persisted in the cerebrospinal fluid at measurable levels for 48 hours after a single injection. Although improvement was temporally related to intrathecal IFN in 1 patient, it is not clear whether this was induced by IFN or a spontaneous remission. A randomized controlled trial would be necessary to evaluate IFN critically as a therapy for SSPE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 303-305 |
| Number of pages | 3 |
| Journal | Annals of Neurology |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1986 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology