Intraoperative fluorescence imaging in thoracic surgery

Andrew D. Newton, Jarrod D. Predina, Shuming Nie, Philip S. Low, Sunil Singhal

Research output: Contribution to journalReview articlepeer-review


Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow®) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

Original languageEnglish (US)
Pages (from-to)344-355
Number of pages12
JournalJournal of Surgical Oncology
Issue number2
StatePublished - Aug 1 2018
Externally publishedYes


  • OTL38
  • indocyanine green (ICG)
  • intraoperative fluorescence imaging (IFI)
  • near-infrared (NIR) fluorescence imaging
  • thoracic surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology


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