Intracellularly grown gold nanoparticles as potential surface-enhanced Raman scattering probes

Ali Shamsaie, Magdalena Jonczyk, Jennie Sturgis, J. Paul Robinson, Joseph Irudayaraj

Research output: Contribution to journalArticlepeer-review


Gold nanoparticles grown within the intracellular confines of living cells are introduced as potential surface-enhanced Raman scattering (SERS) substrates for confocal Raman spectrometry. Electron microscopy and a silver-enhanced reflectance laser scanning confocal microscopic approach were used to visualize the size, shape, and distribution of intracellularly grown gold nanopar-ticles (IGAuN) as small as 1nm. Passive uptake as the conventional approach for delivering nanoparticles inside cells faces the insurmountable challenge of escaping the endosomal/lysosomal pathway. In contrast, IGAuN provides an unprecedented advantage of providing access to cytoplasm and nucleus.

Original languageEnglish (US)
Article number020502
JournalJournal of biomedical optics
Issue number2
StatePublished - Mar 2007
Externally publishedYes


  • Confocal Raman microscopy
  • Confocal reflectance microscopy
  • Gold formation
  • Intracellular growth
  • Silver enhancement
  • Surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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