Intracellular TLR signaling: A structural perspective on human disease

Michael V. Lasker, Satish K. Nair

Research output: Contribution to journalShort survey

Abstract

TLRs are crucial sensors of microbial infection. Maintaining structural integrity of TLR signaling components is essential for subsequent immunological protection. Alterations to the structure of these signaling molecules are often associated with profound clinical outcomes and susceptibility to various infectious diseases. These changes in structure are sometimes the result of a single nucleotide polymorphism (SNP). Numerous SNPs have been found in components of the TLR signaling pathway. Recently, the medical consequences and effects on TLR signaling of several of these SNPs have been elucidated. In addition, there have been numerous structures solved that are important to our understanding of the TLR signaling pathway at the molecular level. The scope of this review is to tie together current structural, biochemical, and genetic information of TLR signaling.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalJournal of Immunology
Volume177
Issue number1
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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