Intracellular osteopontin (iOPN) and immunity

Makoto Inoue, Mari L. Shinohara

Research output: Contribution to journalReview articlepeer-review


Osteopontin (OPN) is a protein involved in various pathophysiological events. OPN has been studied as a secreted protein, but recent reports showed that OPN can be found in the cytoplasm and the nucleus. Therefore, some OPN molecules are not secreted and stay in cells. Such intracellular OPN (iOPN) has biological functions distinct from secreted OPN (sOPN). iOPN is involved in cytoskeletal rearrangement and in signal transduction pathways downstream of innate immune receptors, such as Toll-like receptors (TLRs), as an adaptor or scaffolding protein. Although sOPN and iOPN are generated from the same Opn mRNA species, biological outcomes mediated by two isoforms can be different. It would be necessary to delineate which isoform of OPN is responsible for pathophysiological events.

Original languageEnglish (US)
Pages (from-to)160-172
Number of pages13
JournalImmunologic Research
Issue number1-3
StatePublished - Apr 2011
Externally publishedYes


  • Autoimmune diseases
  • Dendritic cells (DCs)
  • EAE
  • Innate immunity
  • Intracellular OPN (iOPN)
  • MS
  • Osteopontin (OPN)
  • Secreted OPN (sOPN)
  • T helper cell polarization

ASJC Scopus subject areas

  • Immunology


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